Lecture 1. The Coagulation System
Gerald A Soff MD
Presentation Date:
September 4, 2025
> Understanding the Coagulation System is a core part of the foundation for understanding thrombosis and hemostasis. > This presentation will review the history and current understanding of the "Coagulation Cascade.
Gerald A Soff MD
Chief, Classical Hematology Service
University of Miami Health System/Sylvester Comprehensive Cancer Center
Email: gas199@miami.edu
Disclosures for Gerald A Soff MD.
Research Support (Past 2 years):
Amgen, Sobi/Dova Pharmaceuticals
Anthos Therapeutics
Data Safety Monitoring Committee
Alpine Immune Sciences
Advisory Boards (Past 2 years)
Sanofi , Novartis
Learning Objectives:
1. Review the Structure and function of the coagulation Factors.
2. Review the concept of the cell/surface model of assembly of the various coagulation complexes.
3. Review the current understanding of the coagulation "cascade."
4. Review the physiologic anticoagulant processes.
> The classic representation of the Coagulation Cascade.
> We will review the current understanding of the complex pathways of the coagulation system.