Lecture 6: Acquired Bleeding Disorders

Gerald A Soff MD
Chief, General Hematology Service
University of Miami Health System/Sylvester Comprehensive Cancer Center
Email: gas199@miami.edu

OBJECTIVES
1. Understand the differential diagnosis and pathophysiology of different patterns of bleeding.
2. Learn to differentiate disorders of primary hemostasis from bleeding due to coagulation factor deficiencies.
3. Learn when and how to reverse anticoagulation-related bleeding.
4. Understand the mechanism of bleeding from liver dysfunction, vitamin K deficiency, and Disseminated Intravascular Coagulation.

A soft tissue hematoma, indicative of a factor deficiency. The hematoma is raised, warm, and tender to touch.