Lecture 10: Anticoagulation Pharmacology, Use, and Reversal

Lisa M. Baumann-Kreuziger MD, MS
Blood Research Institute, Versiti,
Medical College of Wisconsin.
lisakreuziger@versiti.org

For many decades, heparin was the only choice of parenteral, acute acting anticoagulant (introduced in 1937) and warfarin was the only choice for an oral anticoagulant (introduced in 1954).

With the first introduction of Direct Oral Anticoagulants (DOAC) in 2010, the options for anticoagulation have become safer and more effective, but also more complex.

In this presentation, we will review the Pharmacology, and Reversal of anticoagulants

Blood Research Institute, Versiti, Medical College of Wisconsin.

Andexanet Alfa

•A recombinant form of factor Xa

•Lacks catalytic and membrane-binding activity

•Retains the ability to bind factor Xa inhibitors & TFPI

Lu et al. Nat Med 2013 Apr;19(4):446-5. West J Emerg Med. 2016;17(3):264–270. open access at http://escholarship.org/uc/uciem_westjem