Lecture 9: Functional and Qualitative Disorders of Platelets

Michele P. Lambert MD

Presentation Date:

October 29, 2026

About This Lecture

> Platelets have a critical role in primary hemostasis.

> A wide range of hereditary and acquired disorders impact platelet function, leading to bleeding.

Slide Deck

Continuing Education Credit

Michele P. Lambert MD

Medical Director of the Special Coagulation Laboratory
Attending Physician in the Division of Hematology
Children's Hospital of Philadelphia
LAMBERTM@chop.edu

Speaker Disclosures

Disclosures for Michele P. Lambert MD
> Advisory board member for Octapharma, Dova, Principia, Argenx, Sanofi, Janssen and Shionogi
> Consultant for Novartis, Shionogi, Dova, Principia, Argenx, Rigel, Janssen, Sobi, and Bayer
Research funding from Sysmex, Novartis, Rigel, Principia, Argenx, Dova, Octapharma, Janssen, Sobi and Astra Zeneca
> Coag Lab Research Funds from Rocket Pharmaceuticals and Werfen
> Medical Advisory Board Member for PDSA, CdLS foundation, 22q Society FWG+BD
> Co-Chair of Hemostasis/Thrombosis GCEP and member Platelet Disorder VCEP for ClinGen
> Coagulation Laboratory Research Funding: Rocket Pharmaceuticals; Werfen

Learning Objectives

1. Identify the common clinical presentations of qualitative platelet disorders (platelet function disorders: PFD)
2. Understand the clinical manifestations of PFD and the impact on patients and families
3. Describe the limitations of currently available clinical testing
4. Demonstrate the potential impact of novel therapeutics on patients with inherited platelet disorders
5. List potential acquired causes of platelet dysfunction