Lecture 1: Review of The Coagulation System

Gerald A Soff MD

Presentation Date:

September 3, 2026

About This Lecture

Understanding the Coagulation System is a core part of the foundation for understanding thrombosis and hemostasis. This presentation will review the history and current understanding of the "Coagulation Cascade.

Slide Deck

Continuing Education Credit

Gerald A Soff MD

Chief, Classical Hematology Service
University of Miami Health System/Sylvester Comprehensive Cancer Center
Email: gas199@miami.edu

Speaker Disclosures

Disclosures for Gerald A Soff MD
Research Support (Past 2 years):
Amgen
Sobi/Dova Pharmaceuticals
Anthos Therapeutics
Sanofi
Novartis

Data Safety Monitoring Committee
Alpine Immune Sciences

Learning Objectives

1. Review the Structure and function of the coagulation Factors.
2. Review the concept of the cell/surface model of assembly of the various coagulation complexes.
3. Review the current understanding of the coagulation "cascade."
4. Review the physiologic anticoagulant processes.