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Lecture 6: Acquired Bleeding Disorders

Gerald A Soff MD

Presentation Date: 

October 16, 2025

About This Lecture

  • Hematology Consult for “Bleeding” 

  • Are we working up the patient for actual bleeding episode or history, or simply an abnormal laboratory test. 

  • There are also diseases than can mimic bleeding, i.e. vasculitis. 

  • We will approach the range of mimics, true bleeding disorders, and management.

Speaker Disclosures

Disclosures for Gerald A Soff MD.
Research Support (Past 2 years):
Amgen, Sobi/Dova Pharmaceuticals
Anthos Therapeutics

Data Safety Monitoring Committee
Alpine Immune Sciences

Advisory Boards (Past 2 years)
Sanofi , Novartis

Learning Objectives

1. Understand the differential diagnosis and pathophysiology of different patterns of bleeding.
2. Learn to differentiate disorders of primary hemostasis from bleeding due to coagulation factor deficiencies.
3. Learn when and how to reverse anticoagulation-related bleeding.
4. Understand the mechanism of bleeding from liver dysfunction, vitamin K deficiency, and Disseminated Intravascular Coagulation.

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