Lecture 10: Anticoagulation Pharmacology, Use, and Reversal

Lisa M. Baumann-Kreuziger MD, MS

Presentation Date:

November 13, 2025

About This Lecture

For many decades, heparin was the only choice of parenteral, acute acting anticoagulant (introduced in 1937) and warfarin was the only choice for an oral anticoagulant (introduced in 1954).
With the first introduction of Direct Oral Anticoagulants (DOAC) in 2010, the options for anticoagulation have become safer and more effective, but also more complex.
In this presentation, we will review the Pharmacology, and Reversal of anticoagulants.

Slide Deck

Continuing Education Credit

Lisa M. Baumann-Kreuziger MD, MS

Investigator, Blood Research Institute
Senior Medical Director, Versiti
Professor, Medical College of Wisconsin
lisakreuziger@versiti.org

Speaker Disclosures

Disclosures
> Research funding from Takeda, Sanofi, Veralox, and CSL Behring
> Consulting for HRSA Vaccine Injury Compensation Program

Learning Objectives

At the conclusion of the presentation, the learner should be familiar with the different Direct Oral Anticoagulants (DOAC) as well as warfarin. This should include indications, and management of treatment-related bleeding.