Lecture 28: Thrombotic Microangiopathies/TTP
Mari Thomas MD, PhD
Presentation Date:
May 7, 2026
> Thrombotic Microangiopathies are a range of disorders, characterized by microvascular thrombosis, non-immune hemolytic anemia, and thrombocytopenia.
> These may be life-threatening, and require prompt diagnosis and appropriate intervention.
Dr Mari Thomas
University College London Hospitals, UK
mari.thomas@nhs.net
Disclosures:
Research Support: BHF, Thrombosis UK, Anthos
Advisory Boards (In past 5 years) Sanofi, Bayer, Anthos
Learning Objectives
> What is a Thrombotic Microangiopathy (TMA)?
> Thrombotic Thrombocytopenic Purpura): TTP
> Pathophysiology
> Diagnosis
> Therapies
> Long term effects and monitoring
> Congenital TTP
> Complement mediated HUS
> Other TMA
> Peripheral smear from a patient with sepsis. Note the thrombocytopenia and schistocytes (Fragmented red cells).
> This is consistent with can be seen in a number of disorders with thrombotic microangiopathy (TMA).
> Disseminated intravascular coagulation (DIC) is one TMA entity.
(Image from Gerald A Soff MD)