Lecture 21: Hemolytic Anemia
Rakesh Mehta MD
& Sri Nagalla MD
Presentation Date:
February 26, 2026
> Hemolytic Anemia encompasses a number of acquired and hereditary disorders.
> Recognizing the entities, and mastering the current approach to management is a key component of Classical Hematology Education and practice.
Rakesh Mehta MD
Vice Chair for Education,
Department of Medicine
Indiana University School of Medicine
ramehta@iu.edu
Srikanth Nagalla MD
Chief of Benign Hematology
Miami Cancer Institute
SrikanthN@baptisthealth.net
Disclosure for Rakesh Mehta:
None
Disclosures for Srikanth Nagalla:
Consultant honoraria and advisory board for Alexion, Apellis, Agios, Rigel, SOBI and Sanofi
LEARNING OBJECTIVES
1. Understand the range of hereditary and acquired hemolytic anemia disorders.
2. Understand the presentations and diagnostic workup for hemolytic anemia,
3. Gain mastery on the appropriate treatments for the range of hemolytic anemia disorders.
> This is a classic peripheral smear of a patient with Warm (IgG) Autoimmune Hemolytic Anemia.
> Spherocytes are indicative of IgG mediated hemolytic anemia, (or hereditary spherocytosis).
> The large red cells with a blue color, referred to as polychromatophilia, are young red cells. An increase in young red cells is confirmed with a reticulocyte count and indicates increased red cell production.