Lecture 8: Functional and Qualitative Disorders of Platelets
Michele P. Lambert MD
Presentation Date:
October 30, 2025
> Platelets have a critical role in primary hemostasis.
> A wide range of hereditary and acquired disorders impact platelet function, leading to bleeding
Michele P. Lambert MD
Medical Director of the Special Coagulation Laboratory
Attending Physician in the Division of Hematology
Children's Hospital of Philadelphia
LAMBERTM@chop.edu
Disclosures
> Advisory board member: Janssen, Sobi, argenx, PDSA, 22qSociety and CdLS Foundation
> Consultant: Novartis, Argenx, Agios, Sobi, Sanofi and Janssen
> Research funding: FWGBD, PDSA, Sysmex, Novartis, Principia, Janssen, Argenx, Dova, Octapharma, Sobi and Sanofi.
Leraning Objectives:
1. Discuss Normal platelet function.
2. Review hereditary platelet disorders and the diagnostic tools.
3. Review acquired platelet disorders.
> Genomic landscape of megakaryopoiesis and platelet function defects.
> Schematic cartoon representing the proteins mutated in inherited platelet function disorders.
>Elisa Bianchi et al. Blood 2016;127:1249-1259