Lecture 6: Acquired Bleeding Disorders
Gerald A Soff MD
Presentation Date:
October 16, 2025
Hematology Consult for “Bleeding”
> Are we working up the patient for actual bleeding episode or history, or simply an abnormal laboratory test,
> There are also diseases than can mimic bleeding, i.e. vasculitis.
> We will approach the range of mimics, true bleeding disorders, and management.
Gerald A Soff MD
Chief, Classical Hematology Service
University of Miami Health System/Sylvester Comprehensive Cancer Center
Email: gas199@miami.edu
Disclosures for Gerald A Soff MD.
Research Support (Past 2 years):
Amgen, Sobi/Dova Pharmaceuticals
Anthos Therapeutics
Data Safety Monitoring Committee
Alpine Immune Sciences
Advisory Boards (Past 2 years)
Sanofi , Novartis
OBJECTIVES
1. Understand the differential diagnosis and pathophysiology of different patterns of bleeding.
2. Learn to differentiate disorders of primary hemostasis from bleeding due to coagulation factor deficiencies.
3. Learn when and how to reverse anticoagulation-related bleeding.
4. Understand the mechanism of bleeding from liver dysfunction, vitamin K deficiency, and Disseminated Intravascular Coagulation.
A soft tissue hematoma, indicative of a factor deficiency. The hematoma is raised, warm, and tender to touch.
https://commons.wikimedia.org/wiki/File:Plateletpheresis_hematoma_2016.jpg