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Lecture 4: Von Willebrand Disease

Peter A. Kouides MD
Presentation Date: 
September 25, 2025

> Von Willebrand “Disease” is actually a group of bleeding disorders.
> There are a range of types of vWD.
> The nature of the protein defect determines the inheritance pattern and clinical manifestations.

Peter A. Kouides MD
Clinical Professor of Medicine, University of Rochester School of Medicine
Medical and Research Director, Mary M. Gooley Hemophilia Center, Inc., Rochester NY
peter.kouides@rochesterregional.org
Cell/text: 585-766-3980

Consultant to Uniqure FIX gene therapy trial
Consultant to Tremeau Inc on a hemophiliac arthropathy trial

Learning Objectives
1. Review the structure and function of von Willebrand Factor
2. Review the different types of von Willebrand Disease (vWD)
3. Review the clinical manifestations of vWD
4. Review the different treatment options for vWD, depending on the type.

> Erik Adolf von Willebrand, 1915.

> He first described the disease bearing his name.

> We now understand that there are a number of types of vWD.

Starting in 2025, lectures are eligible for Continuing Education Credit.
Link for CE:  

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