Lecture 2: Laboratory Tests of Hemostasis, Part 1
Gerald A Soff MD
Presentation Date:
September 11, 2025
> Laboratory testing of coagulation provides the tools to diagnose patients with thrombosis and hemorrhage.
> This is the first of two presentations discussing the standard tests of coagulation.
Gerald A Soff MD
Chief, Classical Hematology Service
University of Miami Health System/Sylvester Comprehensive Cancer Center
Email: gas199@miami.edu
Disclosures for Gerald A Soff MD.
Research Support (Past 2 years):
Amgen, Sobi/Dova Pharmaceuticals
Anthos Therapeutics
Data Safety Monitoring Committee
Alpine Immune Sciences
Advisory Boards (Past 2 years)
Sanofi , Novartis
Learning Objectives:
Laboratory Tests of Hemostasis Part 1:
1. Describe analytical principles of routine coagulation screening tests and their clinical utilization.
2. Discuss methods and limitations of clot-based assays, immunoassays, and chromogenic assays.
3. Interpret abnormal coagulation screening test results and what additional testing is recommended.
> The Prothrombin Time & activated Partial Thromboplastin Time are clot-based assays, and the core assays to screen for factor deficiencies.
> Modifications of the assays are used for quantitation of specific factor levels.