Lecture 21: Hemolytic Anemia

Rakesh Mehta MD
& Sri Nagalla MD

Presentation Date:

February 26, 2026

> Hemolytic Anemia encompasses a number of acquired and hereditary disorders.
> Recognizing the entities, and mastering the current approach to management is a key component of Classical Hematology Education and practice.

Rakesh Mehta MD
Vice Chair for Education,
Department of Medicine
Indiana University School of Medicine
ramehta@iu.edu

Srikanth Nagalla MD
Chief of Benign Hematology
Miami Cancer Institute
SrikanthN@baptisthealth.net

> This is a classic peripheral smear of a patient with Warm (IgG) Autoimmune Hemolytic Anemia.

> Spherocytes are indicative of IgG mediated hemolytic anemia, (or hereditary spherocytosis).

> The large red cells with a blue color, referred to as polychromatophilia, are young red cells. An increase in young red cells is confirmed with a reticulocyte count and indicates increased red cell production.

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