Lecture 9: Immune Thrombocytopenia (ITP)

Cindy Neunert MD

Presentation Date:

November 2, 2023

> Immune Thrombocytopenia (ITP) is associated with thrombocytopenia, due to immune platelet destruction.
> It has been over 70 years since an immune mechanism of platelet destruction was recognized, but more detailed understanding of the pathophysiology continues evolve.
> Therapeutic options are also increasing and in this presentation we will review the different modalities.

Cindy Neunert MD
Associate Professor, Pediatrics
Section Head, Pediatric Hematology
Columbia University Medical Center
cn2401@cumc.columbia.edu

> In 1950, William Harrington injected blood from a patient with ITP into himself.

> He developed thrombocytopenia, which was severe but transient.

> This, and other subsequent similar experiments, indicated that ITP was due to a transmissible factor, as the first evidence of an immune mediated component to ITP.

> Harrington et al. J Lab Clin Med 1951;38:1-10

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