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Lecture 8: Functional and Qualitative Disorders of Platelets
Michele P. Lambert MD
Presentation Date:
October 26, 2023
Platelets have a critical role in primary hemostasis.
A wide range of hereditary and acquired disorders impact platelet function, leading to bleeding
Objectives:
1. Recognize the common clinical presentation of qualitative platelet disorders
2. Understand the typical mechanisms by which inherited defects of platelet function occur and list a disorder that exemplifies each mechanism
3. Describe the most common acquired platelet function defects and their clinical presentations.
Michele P. Lambert MD
Medical Director of the Special Coagulation Laboratory
Attending Physician in the Division of Hematology
Children's Hospital of Philadelphia
Genomic landscape of megakaryopoiesis and platelet function defects.
Schematic cartoon representing the proteins mutated in inherited platelet function disorders.
Elisa Bianchi et al. Blood 2016;127:1249-1259
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