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Lecture 19: Sickle Cell Disease
Thomas Harrington MD
Presentation Date:
February 12, 2026
> Sickle Cell Disease (SCD) was first described in 1910.
> SCD was the first disease where a specific mutation
was linked with a hereditary disease. (Pauling, L., Itano, H.A., Singer, S.J. & Wells, I.C. Sickle cell anemia: a molecular disease. Science 110 , 543–548 (1949).)
> While it remains a burden to affected individuals, and their families, research has led to important breakthroughs in management.
Thomas Harrington, MD
University of Miami/Sylvester Comprehensive Cancer Center
tharring@med.miami.edu
> High-Power preipheral smear from patient with sickle cell disease.
> Not the classic sickle shaped red cell. Also, a nucleated red cell.
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