Lecture 8: Functional and Qualitative Disorders of Platelets

Michele P. Lambert MD

Presentation Date:

October 30, 2025

> Platelets have a critical role in primary hemostasis.
> A wide range of hereditary and acquired disorders impact platelet function, leading to bleeding

Michele P. Lambert MD
Medical Director of the Special Coagulation Laboratory
Attending Physician in the Division of Hematology
Children's Hospital of Philadelphia
LAMBERTM@chop.edu

> Genomic landscape of megakaryopoiesis and platelet function defects.

> Schematic cartoon representing the proteins mutated in inherited platelet function disorders.

>Elisa Bianchi et al. Blood 2016;127:1249-1259

Slide Deck

Lecture 8: Functional and Qualitative Disorders of Platelets

Michele P. Lambert MD

Presentation Date:

October 30, 2025

> Platelets have a critical role in primary hemostasis.> A wide range of hereditary and acquired disorders impact platelet function, leading to bleeding​​

> Platelets have a critical role in primary hemostasis.
> A wide range of hereditary and acquired disorders impact platelet function, leading to bleeding