Lecture 14: Antiphospholipid Antibody Syndrome

Shruti Chaturvedi, MBBS, MS

Presentation Date:

January 8, 2026

Antiphospholipid Antibody Syndrome:
> A pro-thrombotic syndrome:
Clinically syndrome, associated with arterial and/or venous thrombosis, and or pregnancy complications.

> Laboratory features: Lupus Anticoagulant, and/or antibodies to beta-2-glycoprotein-1 or cardiolipin.

> Despite decades of clinical research and experience, the pathophysiology remains subject to debate.

Shruti Chaturvedi, MBBS, MS
Johns Hopkins School of Medicine
Baltimore, MD, USA
schatur3@jhmi.edu

Image: C. Lockard Conley, founder of the Division of Hematology at the Johns Hopkins School of Medicine, first described the "Lupus Anticoagulant," an in vitro factor that interfered with coagulation in vitro, but was not associated with bleeding.

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