Lecture 13: Antiphospholipid Antibody Syndrome

David Garcia, MD

Presentation Date:

January 4, 2024

> A pro-thrombotic syndrome:
Clinically syndrome, associated with arterial and/or venous thrombosis, and or pregnancy complications.

> Laboratory features: Lupus Anticoagulant, and/or antibodies to beta-2-glycoprotein-1 or cardiolipin.

> Despite decades of clinical research and experience, the pathophysiology remains subject to debate.

David Garcia, MD
Division of Hematology
University of Washington
davidg99@uw.edu

Image: C. Lockard Conley, founder of the Division of Hematology at the Johns Hopkins School of Medicine, first described the "Lupus Anticoagulant," an in vitro factor that interfered with coagulation in vitro, but was not associated with bleeding.

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